Lee, Seung Joo
Associate Professor
Department of Neurosurgery
Lab of Cerebrovascular Disease, Glioma and Glioblastoma
본 연구실은 신경외과 분야의 기초 및 임상 연구를 통한 중개의학 연구와 외상 및 심정지 이후 뇌 손상 및 무의식 기전에 관한 연구를 수행하고 있습니다.
신경세포의 손상 및 의식 손실은 임상적으로는 중요하지만 기초연구 및 기전 연구는 모호한 실정입니다.
동물 모델 제작을 통해 생체신호 측정 및 분자생물학적 기전 연구를 통해 현재까지 높은 사망률을 보이는 뇌사 환자의 의식 및 신경세포 기능의 회복에 도움이 되고자 합니다.
그 외에도 다양한 뇌 혈관질환인 뇌출혈, 모야모야 병을 비롯한 뇌동맥류 등의 발병기전 및 치료법에 관해 연구하고 있으며 3차원 혈관구조 분석 및 환자 검체를 통한 단백질체 분석, Multiplex IHC등 다양한 접근 방식을 토대로 기초와 임상을 접목시킨 연구를 진행하고 있습니다.
대표 논문
-Lee S, Kim JH, Kim M, Kwon M, Kwon SM, Ko YS, Chung Y, Park W, Park JC, Ahn JS, Jeon H, Lim J. The Efficacy of Therapeutic Hypothermia in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis, Acute and Critical Care, 2024 In press
-Kim M, Kim JH, Park W, Park JC, Ahn JS, Kwun BD, Lee SG, Hwang S, Kim M, Lee S. Risk of Cerebral Aneurysm Rupture After Liver Transplantation: Development and Validation of a Hemorrhagic Stroke Scoring Model. J Korean Med Sci. 2024 Mar 11;39(9):e88. (IF 5.354)
-Kim, J.H., Jeon, H., Kim, M., Lee S. Chemical and perfusion markers as predictors of moyamoya disease progression and complication types. Sci Rep 14, 56 (2024). (IF 4.6) Corresponding author
-Kim JH, Choo YH, Kim M, Jeon H, Jung H-W, Ha EJ, Lee S Neurocritical Care Nutrition: Unique Considerations and Strategies for Optimizing Energy Supply and Metabolic Support in Critically Ill Patients. J Neurointensive Care. 2023;6(2):84-97. Corresponding author
-Cha H, Choi JH, Jeon H, Kim JH, Kim M, Lee S. Aquaporin-4 Deficiency is Associated with Cognitive Impairment and Alterations in astrocyte-neuron Lactate Shuttle. Molecular Neurobiology. 2023;60(11):6212-26. (IF5.682) Corresponding author
-Choo YH, Kim M, Kim JH, Jeon H, Jung H-W, Lee S. The Unique Relationship between Neuro-Critical Care and Critical Illness-Related Corticosteroid Insufficiency : Implications for Neurosurgeons in Neuro-Critical Care. J Korean Neurosurg Soc. 2023;66(6):618-31. (IF 1.6) Corresponding author
-Shim Y, Kim J, Kim HS, Oh J, Lee S, Ha EJ. Intracranial Pressure Monitoring for Acute Brain Injured Patients: When, How, What Should We Monitor. Korean J Neurotrauma. 2023 Jun;19(2):149-161.
-Jeong H, Kim JH, Choo YH, Kim M, Lee S, Ha EJ, Oh J. Nutrition Therapy for Patients With Traumatic Brain Injury: A Narrative Review. Korean J Neurotrauma. 2023 Jun;19(2):177-184
-Kim JH, Jeong H, Choo YH, Kim M, Ha EJ, Oh J, Shim Y, Kim SB, Jung HG, Park SH, Kim JO, Kim J, Kim HS, Lee S. Optimizing Mannitol Use in Managing Increased Intracranial Pressure: A Comprehensive Review of Recent Research and Clinical Experiences. Korean J Neurotrauma. 2023 Jun;19(2):162-176 Corresponding autho
-Kim JH, Choo YH, Jeong H, Kim M, Ha EJ, Oh J, Lee S. Recent Updates on Controversies in Decompressive Craniectomy and Cranioplasty: Physiological Effect, Indication, Complication, and Management. Korean J Neurotrauma. 2023 Jun;19(2):128-148. Corresponding author
- Kim M, Jeon H, Chung Y, Lee SU, Park W, Park JC, Ahn JS, Lee S. Efficacy of Acetylcysteine and Selenium in Aneurysmal Subarachnoid Hemorrhage Patients: A Prospective, Multicenter, Single Blind Randomized Controlled Trial. J Korean Med Sci. 2023 May;38(21):e161
- Choo YH, Kim JH, Jung HW, Kim M, Jeon H, Ha EJ, OH J, Shim Y, Kim SB, Jung HG, Park SH, Kim JO, Kim J, Kim H, Lee S Clinical Application and Significance of Indirect Calorimetry in Neurocritical Care. Journal of Neurointensive Care 2023; 6(1): 1-8.
- JEON H, Byun J, Kang H, Kim K, Lee E, Kim JH, Hong CK, Song SW, Kim Y-H, Chong SJ, Kim JH, Nam SJ, Park JE, Lee S. Proteomic analysis predicts anti-angiogenic resistance in glioblastoma. Journal of translational medicine , 2023
- Jeon H, Kim M, Park W, Lim JS, Lee E, Cha H, Ahn JS, Kim JH, Hong SH, Park JE, Lee EJ, Woo C, Lee S. Upregulation of AQP4 improves blood-brain barrier integrity and perihematomal edema following intracerebral hemorrhage. Neurotherapeutics. 2021 (In press)
- Kim M, Byun J, Chung Y, Lee SU, Park JE, Park W, Park JC, Ahn JS, Lee S. Reactive Oxygen Species Scavenger in Acute Intracerebral Hemorrhage Patients. Stroke. 2021 (Epub ahead of print)
- Park SY, Kim HC, Wee S, Kim YJ, Lim C-M, Kim Y-G, Lee GD, Lee S, Hwang HS, Jang SJ, Lee BH and Cho W-K. Case of a 21-Year-Old Man With Hemoptysis, Recurrent Pneumothorax, and Cavitary Lung Lesions. Chest. 2021;159:e13-e17. (IF 9.657)
- Yang JM, Park CS, Kim SH, Noh TW, Kim JH, Park S, Lee J, Park JR, Yoo D, Jung HH, Takase H, Shima DT, Schwaninger M, Lee S, Kim IK, Lee J, Ji YS, Jon S, Oh WY, Kim P, Uemura A, Ju YS and Kim I. Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis. Circ Res. 2020;126:767-783. (IF 14.467)
- Shin DW, Lee S, Song SW, Cho YH, Hong SH, Kim JH, Kim HS, Park JE, Nam SJ and Kim YH. Survival outcome and prognostic factors in anaplastic oligodendroglioma: a single-institution study of 95 cases. Sci Rep. 2020;10:20162. (IF 3.998)
- Kim M, Jeon S, Roh S. Hong S and Lee S. Treatment outcome and risk factors associated with diffuse axonal injury in patients with moderate to severe head injury. Turkish Neurosurgery. 2020. (IF 0.963) Corresponding author
- Kim M, Park W, Chung Y, Lee SU, Park JC, Kwon DH, Ahn JS and Lee S. Development and validation of a risk scoring model for postoperative adult moyamoya3 disease. Journal of neurosurgery. 2020:1-10. (IF 3.968) Corresponding author
- Kim M, Lee S, Park JC, Jang DM, Ha SI, Kim JU, Ahn JS and Park W. Anaphylactic Shock After Indocyanine Green Video Angiography During Cerebrovascular Surgery. World neurosurgery. 2020;133:74-79. (IF 1.829)
Researcher
전한울
Post-Doc
김소영
MS Researcher
임지현
MS Researcher
이지우
MS Researcher
차혜욱
Ph.D candidate
이은엽
MS Researcher
강하영
Medical student
Clinical research coordinator
이정희
정소영
Contact
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02-3010-2598